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“… Combination of a topical antifungal agent and urea cream yields amazing results within just a few weeks and provides an elegant treatment approach permitting avoidance of oral antifungals …”
B.E. Elewski, MD: Urea Adjunct to Tx of Moccasin Tinea Pedis: Dermatology Times: Oct 1, 2002

“… topical treatments with urea cream and an antifungal, shown in this study to be effective in about the same time interval as that indicated for topical plus systemic therapy, are an advantageous and efficacious alternative…”
B.E. Elewski MD, et al: The Use of 40% Urea Cream in the Treatment of Moccasin Tinea Pedis: Cutis: May 2004: Vol 73: pp 355-357

“… These in vitro results demonstrate the inhibitory activity of urea on dermatophytes, suggesting that this keratolytic agent may also have a fungicide action and that it could be used as an adjuvant in topical treatment…”
J.E.C. Martins: In Vitro Sensitivity of Dermatophytes to Urea: Clinics: 2006: 61 (1): pp 9-14

SYNUROX cream is an emollient, moisturizing and keratolytic cream with mild antifungal properties (SYNUROX is not a medicine). 

SYNUROX cream contains:

  • Urea 30%
  • Piroctone olamine (Octopirox) 0,5%

    Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, keratosis, keratoderma, corns and calluses. Additionally the combination of topical or per os antifungal agents and urea 20-40% (as contained in SYNUROX cream cream) has been shown to improve treatment outcomes. Works synergistically, enhances the effectiveness of the antimycotic agents and results in an earlier improvement of dermatological symptoms. This action of urea 20-40% is supported by several in vitro, as well as in vivo, medical studies. Piroctone olamine (octopirox) is a broad-spectrum antifungal agent (octopirox is not a medicine).

    SYNUROX cream
    • Moisturizes and softens rough and dry skin of the feet
    • Is an ideal adjunct to topical or oral treatment of tinea pedis ( athlete’s foot )
    • Might be used on a maintenance basis, to prevent relapse after curing tinea pedis ( athlete’s foot )
    • Might be used, to prevent athlete’s foot in people who are using frequently facilities as gyms / public showers – locker rooms, swimming pools, etc. 
    • Is ideal for prevention and management of plantar xerosis and callus in diabetic patients (see below)
      Apply a small quantity of SYNUROX cream on the affected area. Rub in until completely absorbed.

    • Adjuvant in antifungal treatment: Twice daily
    • Prevention: Once daily
    • Management / Prevention of diabetic xerosis: Twice daily for 10-15 days. Then, once daily

    For preventive purposes only it should not be administrated to children under 3 years old.

    SYNUROX cream is available in 75ml plastic tubes. 

    SYNUROX and Diabetic Xerosis

    “… High concentration urea-based moisturizes appear to be particulary suitable for removal and prevention of callus, leading to reduced plantar pressures and aiding the prevention of diabetic foot ulcers …”
    T. Pavicic, MD, et al: Xerosis and Callus Formation as a Key to the Diabetic Foot Syndrome. Dermatologic view of the problem and its management: JDDG: 2006: 4: pp 935-941

    • Globaly, about 1.000.000 lower leg amputations are performed, on patients with diabetes, each year
    • 85% of these amputations began as diabetic foot ulcers
    • The cause of diabetic foot ulcer is Xerosis (dry skin) / callus in 18% of cases
    In view of the above mentioned facts, globally, about 153.000 lower leg amputations performed each year on diabetic patients, are due to xerosis / hyperkeratosis / callus formation.

    Xerosis ( dry skin ) is one of the most common skin conditions among diabetic patients. Percentages range from 75% to 82,10%. It is particularly prevalent among elderly patients. If left untreated, xerosis can lead to scaling, fissured skin, and erosions, compromising the barrier function of the skin. This in turn increases the risk of complications such as callus formation, infections and especially ulcerations. Additionaly mycotic ( fungal ) infections may increase the risk of developing “diabetic foot syndrome”.

    It is to be noted that diabetic patients should have their feet examined by a physician on a regular basis.

    Thanks to its 30% urea and 0,5% octopirox, SYNUROX cream is ideal for the management of xerosis and callus in diabetic patients, aiding the prevention of diabetic foot ulcers.

    SYNUROX cream is a gentle, yet potent, tissue softener. Moisturizes effectively and smoothes the skin of the feet. In this way, it fights xerosis, hyperkeratosis and prevent callus formation. Additionaly protects feet from mycotic infections ( tinea pedis ).

    Apply a small quantity on both plantar and dorsal surfaces of the feet. Rub in until completely absorbed.

    For feet application the quantity of one tube (75ml) covers a time period of approximately 40 days (once daily), or 20 days (twice daily).

    Management of Xerosis: Twice daily for 10-15 days

    Maintenance: Once daily

    SYNUROX cream is available in plastic tubes of 75ml.
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